Shanghai Chengzhi Biotechnology Inc., is a professional CRISPR / cas9 gene editing company. We use unique sgRNA screening technology to screen each gene from 4-6 sgRNAs and verify the most efficient sgRNA for cell line gene editing and library construction. Now, we have completed the work including apparent regulatory factors, kinase library and tumor target gene library. At the same time, we provide the customized service of the gRNA library, and specially design the library of specific signal pathways according to the needs of customers, such as disease related pathways: tumor suppressor gene, proto oncogene, diabetes gene, cardiovascular disease gene, Parkinson's disease. Disease genes, etc.; signal transduction pathways: Ras signaling pathway, Wnt signaling pathway, JAK-STAT signaling pathway, NF-kB signaling pathway, TNF signaling pathway, p13k-akt signaling pathway; cell function pathways: autophagy pathway, cell cycle pathway, apoptosis pathway, etc. In addition, according to the specific signal path customization needs of customers, we can design gRNA for personalized customization. Each gene knockout plasmid in all libraries is constructed independently. After screening and verification, we can ensure the 100% coverage and effectiveness of the library genes and greatly improve the success rate of functional screening.

We currently supply these gene libraries and plasmids, viruses and cell line products of all individual genes from stock: at the same time, we also provide functional gene screening services for these libraries. Our goal is to provide professional and high-quality technology and services for researchers engaged in research and development of life science, medicine and clinical diagnosis products.